No - if you use Prime, it breaks the copper/amine bond and releases a flood of free copper into the water, killing the fish. Never use any reducing agent with any of the three main copper products - Cupramine, Coppersafe or Copper Power. They all use ammonia/amines as binders. Undetected reducing agents (even chlorine removers) are likely the culprit in "copper toxicity" instances.So if you use copper should you use something like Seachem prime to “detoxify” the ammonia since copper adds ammonia?
Jay