Any noticeable differences in using this?
Hard to say. I’ve been using it for years alternating with waste away. I think anecdotally that the Dino’s are suppressed for a longer period when I use it (7-10 days vs 4-5 days) but hard to be sure given everything else I’ve been doing.
I will say that I’ve never had any fish diseases or outbreaks while using it.
I do notice that waste away does have an effect on the cleanliness of the tank and sand in general.