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You have to dose powder praziquantel without any solubilizing agent (like what is found in Prazipro). It will take longer to dissolve this way, but IME it is still effective for deworming. I buy mine in bulk from here, and I also add metronidazole to it. But API General Cure achieves the same mix without the hefty "buy in bulk" price tag: http://www.drsfostersmith.com/product/prod_display.cfm?pcatid=16807
Do you recommend doing a water change after the fist treatment with General Cure? Or should I wait until I do the second treatment?