No, laser cutting melts the acrylic and is probably the most stressful method of cutting, and the edge is only marginally weldable if at all. A laser cut edge will craze when you weld it. You "can" laser cut and then route, but the laser cut edge will need to be trimmed back enough to get rid of the affected material that it just isn't worth it. Easier to rough cut with a saw then route.Would it be except able to laser cut all the 3/8" panels instead of cutting them with a router?