Valonia, throwing in the towel, time for the nuclear option, but which red button?

[ElementReefer]

Sounds like you have a solid plan. The effect on algae was not noticeable until ~1 week, so while you certainly could ramp up the dose however you think is best for your tank, you may not see anything happen for a while regardless of dose level.

Fluconazole in animals has an acute LD50 of around 1200 mg/kg. That’s the dose needed to kill 50% of test subjects with one dose. For perspective, that would be a grown man taking about 80,000 mg. The normal dose in humans is up to 400mg a day.

With the caveat that you treat at your own risk, and my info is not professional medical or veterinary advice, fluconazole in animals is a relatively safe drug.

 

[Derrick0580]

As much as most would warn against it I would find the smallest foxface you can get. My lfs get them around 1.5-2 inches. Let it clean up the tank then return it to the lfs.

 

[Shufflepig]

Just saw your thread. I used Fluconazole at 80mg/gal in a 120 gallon system with severe bubble algae outbreak. My observations:
1) No effect on any of the fish in the tank
2) No effect on CUC (snails, hermit crabs)
3) No effect on soft corals or LPS
4) Only SPS effected were 2 montipora which lost their base color but did not die. Several acropora were not effected.
5) Bubble algae began to turn clear and die in about 7 days. 80% of bubble algae died. The bubble algae that lived tended to be in lower light areas. Took about 4 weeks to reach maximum die off.
I never repeated the dose which I believe I should’ve. Over 6 months the bubble algae slowly returned to problem levels.
Will probably try the Fluconazole again but repeat the dose in 4-5 weeks. Been reading about people having success with Brightwells Razor on bubble algae ad well but nobody seems to know what razor actually is.